Translational Biomarker Analytical Core

The Translational Biomarker Analytical Core (TBAC) makes available to Diabetes Research Center investigators a variety of high quality radioimmunoassay and other analyses that are critical to basic, translational and clinical investigators studying diabetes mellitus, insulin resistance, insulin secretion, glucagon dynamics, energy homeostasis, and complications of diabetes. The services provided are best based in a centralized core laboratory because they require special instrumentation and methods that are difficult or impracticably expensive to establish in the laboratories of individual members of the research base. This arrangement also allows for coordinated consultations and improved reliability and reproducibility of the various assays employed. In addition to high quality radio-immunoassay, ELISA, and other analytical methods, TBAC facilitates access of DRC investigators to the measurement of small molecules by targeted metabolomics/lipidomics with the CTSA Biomarkers Core.

Reservations and Prices

Please contact Dr. Blandine Laferrère, MD, PhD to obtain a quote.

Services

  • Consulting services for study design, sample processing, assay methods for diabetes clinical investigators
  • RIA: see list below. Custom assays can be set up after consultation.
  • ELISA: see list below. Custom assays can be set up after consultation.
  • Enzymatic and HPLC assays
  • Lipidomics and metabolomics services

Full list of TBAC services

RIA

  • Adiponectin
  • Cholecystokinin
  • Cortisol
  • C-peptide
  • DHEA
  • Estradiol
  • FSH
  • Total ghrelin
  • Total GLP-1
  • Glucagon
  • hCG
  • Insulin
  • Leptin
  • LH
  • Osteocalcin
  • Progesterone
  • Proinsulin
  • Prolactin
  • PYY total and PYY3-36
  • Resistin
  • T3
  • Testosterone

ELISA

  • Amylin
  • Beta-OH butyrate
  • CRP
  • IL6
  • IL8
  • Insulin
  • GIP
  • GLP-1
  • Proinsulin
  • Insulin
  • Leptin
  • Nandrolone
  • NTX
  • PAI-1
  • TNF-a
  • TPA

Enzymatic

  • Acetaminophen
  • DNA extraction
  • Deuterated glucose
  • FFA
  • Glucose
  • Glycerol
  • Lactate
  • Lipids (cholesterol total, LDL, HDL, triglyceride)
  • Tissue lipid content
  • Triglyceride synthesis

HLPC

  • Catecholamines: dopamine, epinephrine, norepinephrine

Spectrophotometry

  • D-xylose

Quintron Analyzer

  • H2 and methane breath analysis

Bomb Calorimetry

  • Heat, (ash, , lipid, protein)

Targeted Lipidomics

Targeted Metabolomics

Director

Contact

Translational Biomarker Analytical Core
1150 St Nicholas Avenue
Russ Berrie Medical Pavillion
New York, NY 10032
United States